What Is Topical Finasteride?
Over the past few years the drug Finasteride has acquired a reputation for having a high incidence of sexual side effects. This combined with the emergence of “Post Finasteride Syndrome” has resulted in a marked hesitation on the part of many patients to even try this treatment as part of a regimen for treatment of male pattern hair loss (MPH).
Finasteride is a lipophilic drug and can be readily absorbed through the scalp when compounded with regular solvents or penetration enhancers. However, we want to limit the amount of drug entering into the systemic circulation. A new liposomal formulation has been developed to limit the absorption of Finasteride when applied topically. The goal of this formulation is to reduce the incidence of side effects compared to the oral route of administration
Finasteride 2.5% Liposomal Gel is used as an off-label indication to treat alopecia (hair loss). The concentration of this gel provides a daily dose of 25 mg per millilitre (25mg/mL) to be applied topically once daily. Note that this is a much higher concentration compared to the usual oral dose, which is usually 1 to 5 mg taken by mouth 3 to 7 days a week.
This preparation is not FDA or Health Canada approved. You have to have your own physician fill out a prescription for the preparation and the gel will be individually prepared for you.